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BioModels is a repository of mathematical models of biological and biomedical systems. It hosts a vast selection of existing literature-based physiologically and pharmaceutically relevant mechanistic models in standard formats. Our mission is to provide the systems modelling community with reproducible, high-quality, freely-accessible models published in the scientific literature. More information about using BioModels such as model submission, update, publication, or reviewers access can be found in the FAQ.

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Manually Curated

1,096 models

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1,666 models

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833 models
1,096 models
1,666 models
833 models

Model of The Month

September, 2025

Modelling the rabbit cardiac action potential – Can simulations replace the experiment in pharmaceutical cardiosafety assessment?

We performed a comparative benchmark study and investigated a set of 16 mathematical cardiac AP models, including a newly developed minimalistic model specifically tailored to the AP of rabbit Purkinje cells, for their ability to replace the rabbit Purkinje fibre assay. We quantified each model’s ability to reproduce experimental findings by their percentage of generating simulations which match experimental data best...

Model(s) associated with this Model of the Month: BIOMD0000001100.

Last updated by: Dr Marcel Mohr

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How to cite BioModels

Rahuman S Malik-Sheriff, Mihai Glont, Tung V N Nguyen, Krishna Tiwari, Matthew G Roberts, Ashley Xavier, Manh T Vu, Jinghao Men, Matthieu Maire, Sarubini Kananathan, Emma L Fairbanks, Johannes P Meyer, Chinmay Arankalle, Thawfeek M Varusai, Vincent Knight-Schrijver, Lu Li, Corina Dueñas-Roca, Gaurhari Dass, Sarah M Keating, Young M Park, Nicola Buso, Nicolas Rodriguez, Michael Hucka, and Henning Hermjakob
BioModels — 15 years of sharing computational models in life science.
Nucl. Acids Res. 2020
Mihai Glont, Tung V N Nguyen, Martin Graesslin, Robert Hälke, Raza Ali, Jochen Schramm, Sarala M Wimalaratne, Varun B Kothamachu, Nicolas Rodriguez, Maciej J Swat, Jurgen Eils, Roland Eils, Camille Laibe, Rahuman S Malik-Sheriff, Vijayalakshmi Chelliah, Nicolas Le Novère, and Henning Hermjakob
BioModels: expanding horizons to include more modelling approaches and formats.
Nucl. Acids Res. 2018
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Acknowledgements

BioModels is supported by the European Molecular Biology Laboratory, the Biotechnology and Biological Sciences Research Council (Multimod, BB/N019482/1) and the Innovative Medicines Initiative (TransQST, 116030).
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